Contributions of VPS35 Mutations to Parkinson’s Disease
Neuroscience(2019)
摘要
•A mutation in the retromer protein, VPS35, is known to cause PD.•VPS35 mutation affects retromer function, protein homeostasis and mitochondria.•Cell culture and animal models for investigating VPS35 activity are discussed.
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关键词
retromer,neurodegeneration,animal models,cellular mechanisms
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