Estradiol ameliorates antioxidant axis SIRT1-FoxO3a-MnSOD/catalase in the heart of fructose-fed ovariectomized rats

Maja Boskovic,Maja Bundalo,Maja Zivkovic,Jelena Stanisic,Milan Kostic,Goran Koricanac,Aleksandra Stankovic

Journal of Functional Foods（2019）

引用 6|浏览21

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摘要

•10% fructose diet increased AMPK and decreased FoxO3a activity.•10% fructose diet decreased SIRT1, MnSOD and Nox4 protein expression.•Estradiol decreased phosphorylation of cardiac AMPK and FoxO3a in fructose fed rats.•Estradiol enhanced antioxidative capacity in the heart of FRD rats.

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关键词

Metabolic syndrome,Fructose,Estradiol,Heart,miRNA

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