P5411Low Serum Vitamin D Levels Are Associated with Polyunsaturated Fatty Acids, Inflammation and Long-Term Mortality in Patients with Acute Cardiovascular Disease
Acta cardiologica（2018）SCI 4区
Abstract
Nutrition, malnutrition and heart disease 1113 2.31], p<0.001), cerebrovascular (51%; 1.51 [1.19-1.91],p<0.001) and cancer (36%; 1.36 [1.09-1.83],p<0.001) mortality.In the same model, the association between LCD and total mortality was stronger in the non-obese (0.48%) than in the obese (19%) participants.Findings based on the meta-analysis of 7 prospective cohorts with 447,506 participants and 39,326 mortality cases indicted a positive association between LCD and total (RR: 1.15, 95% CI: 1.07-1.22,p<0.001,I2=8.6) (figure 1A), CVD (RR: 1.13, 95% CI: 1.02-1.24,p<0.001,I2=11.2) (figure 1B) and cancer mortality (RR: 1.07, 95% CI: 1.01-1.14,p=0.02,I2=10.3).These findings were robust in sensitivity analyses.Conclusions: Our study highlighted the unfavorable effect of LCD on total and cause-specific mortality, based on both individual data and by pooling previous cohort studies.Given the fact that LCDs may be unsafe, it would be preferable not to currently recommend these diets.Further studies to clarify the mechanisms involved in these associations and to support our findings are eagerly awaited.
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