Strategies for brain-targeting liposomal delivery of small hydrophobic molecules in the treatment of neurodegenerative diseases

•Liposomes are ideal carriers of SHMs.•Liposomal formulation overcomes the undesired properties of SHMs for brain targeting.•Liposome-loaded SHMs are promising for the treatment of NDs.•Strategies for optimizing the liposomal delivery systems are proposed.