Nosocomial Sepsis in VLBW Neonates and Emergence of Antibiotic Resistance: An Epidemiological Study from the Spanish Neonatal Network “Grupo Castrillo”

Introduction: Nosocomial sepsis (NS) is a serious problem in very-low-birth-weight (VLBW) infants and a leading cause of neonatal morbidity and mortality. Their high frequency is related to the immaturity host defenses, frequent exposure to invasive diagnostic and treatment procedures, and prolonged hospital stay of these infants. The emergence of multiresistant bacteria is a serious problem in the management of these infections. The objective of this study was to assess the epidemiology of NS in VLBW infants in Spain.