One Year Follow-Up Results of Phase I/II Clinical Trial for Combined Treatment of Chronic Wounds with Dermal Equivalent-Assisted Skin Autograft

Successful surgical treatment of chronic wound defects remains an actual problem. Recently the cell therapy and tissue engineering approaches have been proposed for their treatment. The aim of a study was to assess the effectiveness of dermal equivalent (DE) application for wound bead preparation and explore the mechanisms of its action in patients with chronic wounds.