Immunedysregulatory Events in Hodgkin’s Disease.

Background and Aims: Impairment of cell-mediated immunity has long been recognized in classical Hodgkin's lymphoma (cHL), but it is still under discussion whether the ineffective immune clearance of Hodgkin/ Reed-Sternberg (H/R-S) cells is exclusively resulting from the immunosuppressive environment at the tumor site or might be due to a primary T cell defect. Therefore, we applied a microarray approach in order to analyze circulating T lymphocytes for specific dysregulation.