Reinvestigation of Ortho-Amidoacetophenones' Cyclization Mediated by Trimethylsilyl Trifluoromethanesulfonate. the Lewis-acid-assisted and Brønsted-acid-catalyzed Reaction

Reinvestigation the synthesis of quinolones from ortho-amidoacetophenones by trimethylsilyl trifluoromethanesulfonate (TMSOTf) mediated reaction is reported. In addition to receiving the expected quinolones, an unexpected intermolecular self-condensation adduct was also isolated. The detailed mechanism of its formation is discussed.