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A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection

Nurgun Kose,Julie M. Fox,Gopal Sapparapu,Robin Bombardi,Rashika N. Tennekoon,A. Dharshan de Silva,Sayda M. Elbashir, Matthew A. Theisen,Elisabeth Humphris-Narayanan,Giuseppe Ciaramella,Sunny Himansu,Michael S. Diamond,James E. Crowe

Science Immunology（2019）

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摘要
Lipid nanoparticles containing mRNA encoding a human antibody for chikungunya virus protect against infection and arthritis.
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