Retrospective analysis of model-based predictivity of human pharmacokinetics for anti-IL-36R monoclonal antibody MAB92 using a rat anti-mouse IL-36R monoclonal antibody and RNA expression data (FANTOM5).

Jennifer Ahlberg,Craig Giragossian,Hua Li,Maria Myzithras,Ernie Raymond,Gary Caviness,Christine Grimaldi,Su-Ellen Brown,Rocio Perez,Danlin Yang,Rachel Kroe-Barrett,David Joseph,Chandrasena Pamulapati,Kelly Coble, Peter Ruus,Joseph R Woska,Rajkumar Ganesan,Steven Hansel,M Lamine Mbow

MABS（2019）

引用 7|浏览54

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关键词

TMDD,target-mediated drug disposition,nonlinear pharmacokinetic,surrogate,cross-species,monoclonal antibody,expression,FANTOM,CAGE,mechanistic modeling,human prediction,semi-mechanistic,modeling,RNA transcriptome

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