Tumor Targeted Micellar Nanocarriers Assembled from Epipodophyllotoxin-Based Amphiphiles
Nanoscale(2019)
摘要
Micelle-forming amphiphilic drug conjugates were synthesized starting from a biologically active epipodophyllotoxin derivative which was covalently inserted in between a hydrophilic PEG unit and a hydrophobic stearyl chain. The epipodophyllotoxin-containing amphiphiles were assembled into the corresponding micelles which were evaluated in vivo for their tumor targeting properties.
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