Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases: protocol of a multicentre, open-label, parralel-group, phase II-III, randomised, superiority study (CAIRO6).

Koen P Rovers,Checca Bakkers,Geert A A M Simkens,Jacobus W A Burger,Simon W Nienhuijs,Geert-Jan M Creemers,Anna M J Thijs,Alexandra R M Brandt-Kerkhof,Eva V E Madsen,Ninos Ayez,Nadine L de Boer,Esther van Meerten,Jurriaan B Tuynman,Miranda Kusters,Nina R Sluiter,Henk M W Verheul,Hans J van der Vliet,Marinus J Wiezer,Djamila Boerma,Emma C E Wassenaar,Maartje Los,Cornelis B Hunting,Arend G J Aalbers,Niels F M Kok,Koert F D Kuhlmann,Henk Boot,Myriam Chalabi,Schelto Kruijff,Lukas B Been,Robert J van Ginkel,Derk Jan A de Groot,Rudolf S N Fehrmann,Johannes H W de Wilt,Andreas J A Bremers,Philip R de Reuver,Sandra A Radema,Karin H Herbschleb,Wilhelmina M U van Grevenstein,Arjen J Witkamp,Miriam Koopman,Nadia Haj Mohammad,Eino B van Duyn,Walter J B Mastboom,Leonie J M Mekenkamp,Joost Nederend,Max J Lahaye,Petur Snaebjornsson,Cornelis Verhoef,Hanneke W M van Laarhoven,Aeilko H Zwinderman,Jeanette M Bouma,Onno Kranenburg,Iris van 't Erve,Remond J A Fijneman,Marcel G W Dijkgraaf,Patrick H J Hemmer,Cornelis J A Punt,Pieter J Tanis,Ignace H J T de Hingh

BMC Cancer（2019）

引用 85|浏览30

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关键词

Colorectal neoplasms, Peritoneal neoplasms, Cytoreduction surgical procedures, Hyperthermia, induced, Neoadjuvant therapy, Adjuvant chemotherapy, Bevacizumab, Randomized controlled trial, Mortality, Progression-free survival

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