Secosterol-B affects endoplasmic reticulum structure in endothelial cells.

Francesca Luchetti,Rita Crinelli,Maria Gemma Nasoni,Erica Cesarini,Barbara Canonico,Loretta Guidi,Chiara Zerbinati,Mauro Magnani,Stefano Papa,Luigi Iuliano

The Journal of Steroid Biochemistry and Molecular Biology（2019）

引用 11|浏览60

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摘要

•Secosterol-B induces ER stress in HUVEC.•Secosterol-B triggers pro-survival signaling through autophagy and UPS.•eIF2α phosphorylation and NF-kB activation involved in the secosterol-B-induced apoptosis.

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关键词

ANNEX-V,EC,eIF2α,ER,FC,GFP,HUVEC,ISR,MDC,OxLDL,PI,SEC-B,SDS,UPR,UPS

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