PO 2 oscillations induce lung injury and inflammation.

Stefan Boehme,Erik K Hartmann,Thomas Tripp, Serge C Thal,Matthias David,Dietmar Abraham,James E Baumgardner,Klaus Markstaller,Klaus U Klein

Critical care (London, England)（2019）

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摘要

Artificial mixed-venous PO oscillations induced lung damage and pulmonary inflammation in healthy animals during lung protective ventilation. These findings suggest that PO oscillations represent an independent mechanism of VILI.

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关键词

Cyclic recruitment and derecruitment of atelectasis,Inflammation,Lung injury,PO2 oscillations,Pathomechanism,Veno-venous extracorporeal membrane oxygenation,Ventilator-induced lung injury

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