Manipulation of gut microbiota blunts the ventilatory response to hypercapnia in adult rats.

Karen M O'Connor,Eric F Lucking,Anna V Golubeva,Conall R Strain,Fiona Fouhy,María C Cenit, Pardeep Dhaliwal,Thomaz F S Bastiaanssen,David P Burns,Catherine Stanton,Gerard Clarke,John F Cryan,Ken D O'Halloran

EBioMedicine（2019）

引用 37|浏览22

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摘要

Chronic antibiotic administration and faecal microbial transfer disrupt gut microbiota, brainstem monoamine concentrations and the ventilatory response to hypercapnia. We suggest that aberrant microbiota-gut-brain axis signalling has a modulatory influence on respiratory behaviour during hypercapnic stress. FUND: Department of Physiology and APC Microbiome Ireland, University College Cork, Ireland.

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ABX,AIH,BH,DA,Dia,EMG,ETCO2,FDR,FLASH,FMT,fR,FiCO2,FiO2,Hb,HVA,L-DOPA,NA,OTUs,PBG,PBS,PCoA,PaCO2,PD whole tree,PaO2,QIIME,SaO2,SD1,SD2,Te,Ti,Ttot,VCO2,VE,VEH,VE/Vco2,VO2,VT,VT/Ti,5-HIAA,5-HT,5-HT3

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