Effects of a selanylimidazopyridine on the acute restraint stress-induced depressive- and anxiety-like behaviors and biological changes in mice.

Micaela Domingues,Angela Maria Casaril,Paloma Taborda Birmann,Suely Ribeiro Bampi,Darling de Andrade Lourenço,Beatriz M Vieira,Luiz H Dapper,Eder J Lenardão,Mariana Sonego,Tiago Collares,Fabiana K Seixas,César Augusto Brüning,Lucielli Savegnago

Behavioural Brain Research（2019）

引用 38|浏览8

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摘要

•MPI abolishes depressive/anxiogenic-like phenotypes in ARS mice.•MPI mitigates GR receptor phosphorylation-ARS induced by targeting GSK3-B.•MPI prevents oxidative/nitrosative stress in ARS mice.•MPI prevents neuroinflammation by targeting NFKB.•MPI abolishes BDNF downregulation induced by ARS.

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关键词

Depression,Mood disorders,Stress,Selenium,Animal models

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