MDM2 Amplification Levels Are Not Correlated to the Degree of Dedifferentiation and Metastatic Potential in Well Differentiated and Dedifferentiated Liposarcoma

Fan Foon Cheo,Winston Hong Wern Chew,Jason Yongsheng Chan,Mohamad Farid,Wei Lin Goh, John Heng Chi Lim,Sze Huey Tan,Nagavalli Somasundaram,Eileen Yi Ling Poon,Alvin Soon Tiong Lim,Tse Hui Lim,Mann Hong Tan,Khee Chee Soo,Melissa Teo,Timothy Kwang Yong Tay,Sathiyamoorthy Selvarajan,Richard Quek,Kesavan Sittampalam

Pathology（2018）

Cited 0|Views49

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Abstract

Aim: MDM2, a gene consistently amplified in well differentiated (WD) and dedifferentiated (DD) liposarcomas (LPS), is an oncogene that inhibits the p53 pathway. Fluorescent in situ hybridisation (FISH) of MDM2 is reportedly the diagnostic gold standard for WD/DD LPS. However, the prognostic utility of this biomarker is less well established. This study aims to examine MDM2 amplification as a predictor of dedifferentiation and metastasis in LPS.

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