The Stromal Niche For Epithelial Stem Cells: A Template For Regeneration And A Brake On Malignancy
CANCER CELL(2017)
摘要
Stromal restraint of cancer growth and progression-emerging as a widespread phenomenon in epithelial cancers such as bladder, pancreas, colon, and prostate-appears rooted in stromal cell niche activity. During normal tissue repair, stromal niche signals, often Hedgehog-induced, promote epithelial stem cell differentiation as well as self-renewal, thus specifying a regenerating epithelial pattern. In the case of cancerous tissue, stromal cell-derived differentiation signals in particular may provide a brake on malignant growth. Understanding and therapeutic harnessing of the role of stroma in cancer restraint may hinge on our knowledge of the signaling programs elaborated by the stromal niche.
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关键词
epithelial stem cell niche,hedgehog signaling,cancer progression,differentiation therapy,epithelial stromal signaling,regeneration
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