Flavonoids from the Amazon plant Brosimum acutifolium induce C6 glioma cell line apoptosis by disrupting mitochondrial membrane potential and reducing AKT phosphorylation.

L A L Maués,G M Alves, N M G Couto,B J M da Silva, M S P Arruda,B M Macchi,C B C Sena,A F Prado,M E Crespo-Lopez,E O Silva,J L M do Nascimento

Biomedicine & Pharmacotherapy（2019）

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摘要

•BAS-4 from the Amazonian plant B. acutifolium inhibits glioblastoma migration.•BAS-4 disrupts the C6 cell cycle and reduces mitochondrial transmembrane potential.•BAS-4 inhibits AKT phosphorylation to reduce C6 proliferation and promote apoptosis.•Flavonoids should be studied as novel cancer therapeutics.

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ΔΨm,μM,AKT,BAS,DMSO,IC50,MTT,pAKT

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