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Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity.

Xiaoling Xie,Daniel Baird, Kimberly Bowen,Vladimir Capka,Jinyun Chen,Gregg Chenail,YoungShin Cho,Julia Dooley,Ali Farsidjani,Pascal Fortin,Darcy Kohls,Raviraj Kulathila,Fallon Lin,Daniel McKay,Lindsey Rodrigues,David Sage,B Barry Touré, Simon van der Plas,Kirk Wright,Ming Xu,Hong Yin,Julian Levell,Raymond A Pagliarini

Structure（2017）

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关键词
Isocitrate dehydrogenase,IDH1,IDH2,2-hydroxyglutarate,2-HG,targeted therapy,oncology
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