Association Between BRCA1 Polymorphisms Rs799917 and Rs1799966 and Breast Cancer Risk: a Meta-Analysis

Background Several studies have reported correlations between BRCA1 polymorphisms rs799917 and rs1799966 with the risk of breast cancer (BC). However, this relationship remains controversial. Methods We conducted a meta-analysis of seven studies to assess the associations between BRCA1 rs799917 and rs1799966 and BC risk, with the aim of more accurately determining the potential correlation. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated to evaluate the correlation of rs799917 and rs1799966 with BC risk. Results There was no overall correlation between BRCA1 rs799917 and BC risk (TT vs CC: OR = 0.87, 95% CI = 0.66-1.16; CT vs CC: OR = 1.02, 95% CI = 0.89-1.15; dominant model: OR = 0.99, 95% CI = 0.88-1.11; recessive model: OR = 0.87, 95% CI = 0.65-1.16). Subgroup analysis by ethnicity also revealed no significant correlation between rs799917 and BC risk in either Asians or Caucasians. There was also no significant association between BRCA1 rs1799966 and BC risk (GG vs AA: OR = 0.70, 95% CI = 0.33-1.47; AG vs AA: OR = 0.68, 95% CI = 0.35-1.30; dominant model: OR = 0.76, 95% CI = 0.49-1.06; recessive model: OR = 0.82, 95% CI = 0.49-1.36). Conclusion BRCA1polymorphisms rs799917 and rs1799966 were not significantly associated with BC risk in this meta-analysis.