Probiotic microorganisms detoxify ochratoxin A in both a chicken liver cell line and chickens.

BACKGROUNDThe administration of probiotics and prebiotics (synbiotics) is a promising method for detoxification of ochratoxin A (OTA) in animals. The aim of this study was to investigate the ability of five probiotic strains of lactic acid bacteria (LAB) and one Saccharomyces cerevisiae yeast strain, from three different synbiotics for poultry, to detoxify OTA. In addition, we also investigated the genotoxicity of faecal water (FW) of chickens after administering OTA and/or synbiotics for 42days. RESULTSAll tested LAB and yeast strains had the ability to detoxify OTA by significant (P<0.05) reducing its concentration (by 31.3-47.7% and 31.9%, respectively, after 24h incubation) and genotoxicity (by 22.6-51.8% and 52.7%, respectively). Synbiotics composed of four and five probiotic strains significantly (P<0.05) decreased FW genotoxicity of chicks, after exposure to OTA, to the level seen in the control group (21.8%1.7%) and were more effective than synbiotics composed of three probiotic strains (31.5%). CONCLUSIONThese results showed that there was a beneficial effect of the synbiotics on the gastrointestinal tract of animals. Furthermore, synbiotic preparations containing four or five of tested strains can be considered as preventive agents in the contamination of poultry with OTA. (c) 2019 Society of Chemical Industry