T-cell mitochondrial dysfunction and lymphopenia in DOCK2-deficient patients.

Mohammed F Alosaimi,Hiba Shendi,Abdallah Beano,Kelsey Stafstrom,Rabab El Hawary,Safa Meshaal,Nermeen Galal,Sung-Yun Pai,Aisha El-Marsafy,Raif S Geha,Janet Chou

The Journal of allergy and clinical immunology（2019）

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摘要

This study delineates the mitochondrial defects in DOCK2-deficient T cells contributing to the T cell lymphopenia characteristic of this primary immunodeficiency.

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