P-11CLASS I ALCOHOL DEHYDROGENASE (ADH1) IS INDISPENSABLE FOR CONTINUOUS ALCOHOL DRINKING TO DEVELOP ALCOHOLISM

T. Haseba, M. Maruyama, T. Akimoto,Y. Ohno

Alcohol and alcoholism（2015）

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摘要

The development of alcoholism depends solely on chronic alcohol intake, which increases alcohol metabolism and induces organ diseases. There is little knowledge what makes possible continuous alcohol drinking, though ADH1 is known to be a key enzyme of alcohol metabolism. We investigated how ADH1 regulates continuous drinking, by using Adh1-/- , together with …

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