The First Kilogram Synthesis of Beclabuvir, an HCV NS5B Polymerase Inhibitor

Jeffrey Bien,Akin Davulcu,Albert J. DelMonte,Kenneth J. Fraunhoffer,Zhinong Gao,Chao Hang,Yi Hsiao, Wenhao Hu,Kishta Katipally, Adam Littke, Aghogho Pedro,Yuping Qiu, Maria Sandoval,Richard Schild,Michelle Soltani, Anthony Tedesco,Dale Vanyo,Purushotham Vemishetti,Robert E. Waltermire

Organic process research & development（2018）

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asymmetric,cyclopropanation,direct arylation,palladium,rhodium,catalysis

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