Chop Serves As A Positive Feedback Toward Activation of Camkii in Er Stress Mediated-Apoptosis and Cardiac Dysfunction: Novel Signaling Pathway in Cardiac Pressure Overload

Introduction: Increased apoptosis accompanies the transition from compensated left ventricular (LV) hypertrophy to failure. CCAAT-enhance-binding protein homologous protein (CHOP) is a key molecule...