Polymer Insulin Derivatives: Application Peculiarities

Using the polymer model of small intestine, it is shown that the dependence of the efficiency of the preparation Ransulin on the size of an animal is due to a difference in the diameter of the small intestine and the enhanced enzymatic hydrolysis of insulin accompanying its diffusion from the intestine with a larger diameter. Unlike hypodermic injections, in the oral administration of preparations, insulin is initially accumulated in the liver and only then is transported into the bloodstream; that is, the physiological pathway of insulin secretion is realized.