Two Novel Zn(Ii)-Li(I)-Based And In(Iii)-Based Coordination Polymers: Crystal Structures And Anti-Lung Cancer Activity

In this study, two new metal-organic frameworks, namely, {(H2NMe2)[Zn3LiO(BTA)(2)](DMF)(3)}(n) (1, H(3)BTA = 3,3',3 ''-[1,3,5-benzenetriyltris(carbonylimino)]trisbenzoic acid) and {(Me2NH2)(2)[In-2 (TTA)(2)(FBA)(2)](DMF)(3)}(n) (2, H(3)TTA=4,4'4(((5-((4-(hydroxy-12-methoxy)phenoxy)methyl)-2,4 ,6- trimethyl-1,3-phenylene)bis(methylene))bis(oxy))dibenzoic acid, HFBA = 2-fluorobenzoic acid), were obtained via a one-pot solvothermal reaction of metal salts and organic connectors. The structures of the title two metal-organic coordination compounds were structurally probed via X-ray single crystal diffraction technique. In connection to their structures, the MTT assay was used to access the in vitro antitumor activities for compounds 1 and 2 against the human lung cancer cells (MSTO-211H, NCI-H1299 and NCI-H292).