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A Novel Square-Planar Pt(ii) Complex As a Monomeric and Dimeric G-quadruplex DNA Binder

Chun-Qiong Zhou,Zi-Qi Li,Ting-Cong Liao,Tian-Zhu Ma,Shuo-Bin Chen,Yuan-Yuan Liang

RSC advances（2018）

Cited 4|Views9
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Abstract
A novel phenanthroimidazole ethylenediamine Pt(ii) complex with coumarin derivative (1) was synthesized and showed higher affinity, selectivity and thermal stabilization for mixed-type dimeric G-quadruplexes (G2T1) over monomeric G-quadruplexes (G1) and duplex DNA. Complex 1 could bind to G-quadruplexes via end-stacking and external-binding modes.
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