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F137. Locus Coeruleus Signal Intensity is Decreased in Patients with Late-Life Depression Treated with Noradrenergic Agents

Biological psychiatry(2018)

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摘要
The Locus Coeruleus (LC), the major source of noradrenergic neurotransmission, can be visualized with neuromelanin-sensitive MRI. Although decreased signal intensity has been found in neurodegenerative and psychiatric disorders, it is not clear whether such alteration is similar across conditions and what confounding sources should be considered.
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关键词
Late Life Depression,MCI,Locus Coeruleus,SNRI (Serotonin-Norepinephrin Reuptake Inhibitor),Structural MRI
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