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214. Genome-Wide DNA Methylation Analysis of High-Dose Synthetic Glucocorticoid Administration Across Peripheral Tissues and Brain in Humans

Biological psychiatry(2018)

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摘要
An imbalance of glucocorticoids has been implicated in stress-related disorders. Within mouse models, differential methylation in response to glucocorticoid treatment has been shown. However, within humans the extent to which glucocorticoids affect DNA methylation (DNAm) across the genome is unknown.
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关键词
Epigenetics,DNA Methylation,Corticosteroids,Glucocorticoids,PTSD - Posttraumatic Stress Disorder
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