National Quality Control and Validation of Hepatitis C NS3, NS5A and NS5B Genotypic Resistance Testing

T. Ruggiero,V. Cento,M. Aragri, M. Arosio,F. Baldanti,M. Brunetto,B. Bruzzone,E. Boeri,D. Cavallone, N. Coppola,M. Di Stefano,V. Ghisetti, A. P. Callegaro,M. R. Capobianchi,C. Caudai,N. Cuomo,S. Galli,E. Galmozzi,A. R. Garbuglia,W. Gennari,A. Lai,S. Menzo,V. Micheli,C. Minosse,L. Monno,S. Paolucci,T. Pollicino, A. Raddi,G. Raffa,G. Raimondo,M. Sanguinetti, M. Sampaolo,R. Santangelo,T. Santantonio, S. Soldini,M. Starace,M. L. Vatteroni,A. Craxi,C. F. Perno, F. Ceccherini-Silberstein,M. Zazzi

Journal of hepatology（2018）

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摘要

Introduction and aim: International guidelines recommend HCV genotypic-resistance-testing (GRT) in selected cases, however, GRT application is limited in many countries by the lack of a commercial-assay. Within the Italian VIRONET-C, we conducted a multicentre HCV Sanger-GRT quality control study with the aim of providing a standardized GRT at National-level.

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