Sequence‐Specific DNA Recognition with Designed Peptides
European Journal of Organic Chemistry(2018)
摘要
Inspired by natural transcription factors (TFs), researchers have explored the potential of artificial peptides for the recognition of specific DNA sequences, developing increasingly sophisticated systems that not only display excellent DNA binding properties, but also are endowed with new properties not found in their natural counterparts. Here we review some of the developments in the field of artificial peptide-based DNA binders, focusing on the supramolecular and molecular design aspects of such systems.
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关键词
Supramolecular chemistry,Peptides,DNA recognition,DNA binding,DNA,Metallopeptides,Chemical biology
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