RELATIONSHIP BETWEEN STRUCTURAL CHANGES OF BRAIN AND COGNITIVE FUNCTION AND SURVIVAL RATE IN ALZHEIMER'S DISEASE PATIENTS

Alzheimer's disease have shown generally macroscopic and microscopic structural changes in previous studies. These changes have many implications for cognitive change and survival rate. The aims of this study are to investigate relationship between structural changes and cognitive function and survival rate in alzheimer's disease patients. Recruited 42 Alzheimer's disease patients through chart review in general hospital. Data collections (Demographic data, MR Imaging-Global cortical atrophy scale-GCS, Koedam scale of posterior atrophy, Medial temporal atrophy scale-MTA, Fazekas scale). Charlson comorbidity index(CCI) and calculator(10 year survival rate, CCI10) . MMSE-K(baseline, 1 year follow up). Statistic analyses(IBM SPSS statistics 23.0)-Hypothesis Testing(Spearman Correlation Analysis, Multiple Regression Analysis) Demographic & Clinical Data (1) Samples: Men 12, Women 30, Total 42 (2) Mean Age(Men 76.17±8.91, Women 79.70±6.03, Total 78.69±7.05) (3) BMI (Men 24.35±3.70, Women 24.36±2.44, Total 24.36±2.81) (4) Charlson comorbidity index(CCI, Men 7.00±1.41, Women 6.47±1.91, Total 6.62±1.78) (5) 10year survival rate by CCI (Men 4.12±8.11%, Women 12.12±8.11%, Total 9.84±15.26%) (6) MMSE-K(Baseline, Men 21.00±4.59, Women 20.53±4.57, Total 20.67±4.52; 1 year follow up, Men 21.83±5.61, Women 20.53±4.57, Total 20.10±5.68), MR Mean(GCS-Left 1.26±0.77, GCS-Right 1.24±0.76, Koedam-Left 0.71±0.86, Koedam-Right 0.57±0.83, MTA-Left 1.12±0.86, MTA -Right 1.12±0.97, Fazekas 1.10±0.85) . Correlation(Spearman) Analyses(**p=0.01, *p=0.5) : CCI/CCI10**, MMSE-K-1/MMSE-K-B**, MR-GCS-Rt/MR-GCS-Lt**, MR-Koedam-Lt/MR-GCS-Lt**, MR-Koedam-Lt/MR-GCS-Rt**, MR-Koedam-Rt/MR-GCS-Lt**, MR-Koedam-Rt/MR-GSC-Rt**. MR-Koedam-Rt/MR-Koedam-Lt**, MR-/MMSE-K-B*, MR-MTA-Lt/MR-GCS-Lt**, MR-MTA-Lt/MR-GCS-Rt*, MR-MTA-Rt/MMSE-K-B*, MR-MTA-Rt/MR-GCS-Lt**, MR-MTA-Rt/MR-GCS-Rt*, MR-MTA/Rt-MR-MTA-Lt**, MR-Fazekas-MMSE-K-B*, MR-Fazekas/Mr-GCS-Lt*, MR-Fazekas/Mr-GCS-Rt*, MR-Fazekas/MR-MTA-Lt**, MR-Fazekas/MR-MTA-Rt**. Multiple Regression Analysis : MR-MTA-Rt(predictor)/MMSE-K-B Dependent variable(F=8.275, p=0.006), MR-GCS-Rt(predictor)/MMSE-K-1 Dependent variable(F=7.174, p=0.011), MR-GCS-Rt(predictor)/CCI-10(F=4.255, p=0.046). The above results show that right medial temporal atrophy and global cortical atrophy in brain can influence cognition problems(baseline, 1 year) . Also, those show that right global cortical atrophy in brain have some relation with 10 year survival rate by Charlson comorbidity index (CCI).