Risk Factors of Afatinib Induced Diarrhea: A Retrospective Study

Yuki Ueda,Hidekazu Suzuki,Yoko Kondo,Norio Okamoto,Akinori Kumode,Naoko Usui,Hiroyuki Nakano, Takashi Kimura,Masumi Sando,Kazuko Shimura,Emiko Tanaka,Chie Mochizuki,Tomonori Hirashima

Japanese Journal of Pharmaceutical Health Care and Sciences（2016）

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摘要

Afatinib is an irreversible oral ErbB family blocker. It demonstrates a side-effect profile similar to that by the first-generation epidermal growth factor receptor-tyrosine kinase inhibitor, with diarrhea being the most frequently reported adverse event (AE). Moderate and severe diarrhea can have a significant effect on patients' quality of life (QOL).

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关键词

afatinib induced diarrhea,risk factors

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