Lipid Profile Abnormalities among Nigerian Male Renal Failure Patients on Dialysis

Cardiovascular diseases are the leading cause of mortality and morbidity in developed countries and they are emerging as prominent public health problem in developing countries [1]. In this World Health Organization [1] report, it was stated that 80% of deaths from cardiovascular diseases and 87% of related disability currently occur in low and middle income countries. It was revealed in a study conducted in Nigeria by Adedorin and Adesoye [2] that men (60.8%) have higher incidence of cardiovascular disorders than women (39.2%). Shakaib et al. [3] confirmed in their study the existence of ethnic differences in hypertension control, and in cardiovascular and renal outcomes, which they attributed to factors such as biological, cultural, social, healthcare system. There is an association between cardiovascular disease and renal failure, and dyslipemia is said to contribute to development of cardiovascular disease and renal disease progression. Abrass [4] in animal studies observed that hypercholesteremia increases the rate of progression of kidney disease. A high-fat diet causes macrophage infiltration and foam cell formation in rats leading to glomerusclerosis [5].