Improved survival in an exhaustive population based on a cohort of liposarcoma (LPS) patients treated in expert centers according to clinical practice guidelines (CPG'S): Experience from Rhone Alpes (RA) region.

10581 Background: Liposarcoma (LPS) represents the most common soft-tissue sarcoma.The aim of this prospective and exhaustive population-based study is to explore the impact of medical practices conformed to CPGu0027s on survival of patients with localized LPS in a region of 6 million inhabitants. Methods: Between 2005 and 2007, 133 patients out of 141 with an initial diagnosis of localized LPS and residing in the RA region (France), were enrolled. The prognostic impact of adherence to CPGs on progression-free survival (PFS) and overall survival (OS) was assessed with a multivariate Cox model analysis including all potential prognostic factors (PF). Results: The median age was 61 years (range 26-89). Sex ratio: M/F was 1.5; the histological subtypes were: well differentiated LPS (n=86, 64.5%), dedifferenciated LPS (n=29, 22%), myxoid (n=12, 9%) and pleiomorphic (n= 6, 4.5 %). Histological grade was low in 96 patients (73%), intermediate in 16 (17%) high in 12 (9%) and unknown in 2 (1%), 48.8% of tumors were l...