Meeting the needs of breast cancer: A nucleolin’s perspective

•Nucleolin supports tumorigenesis, metastization and angiogenesis.•Nucleolin’s overexpression is an unfavorable prognostic factor.•Nucleolin is overexpressed in primary breast tumors and their lymph node metastases.•Nucleolin is overexpressed in endothelial cells of breast tumor blood vessels.•Nucleolin can enable novel mechanisms of breast tumor drug targeting.