Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies
Bioorganic & Medicinal Chemistry Letters（2017）
关键词
M5,Muscarinic acetylcholine receptor,Pharmacokinetics,CNS penetration,Structure-Activity Relationship (SAR)
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