MicroRNA function in Drosophila memory formation

•RISC is required for activity-dependent and sensory-specific protein translation.•RISC and associated proteins are required for olfactory long-term habituation.•MiR-276a regulates long-term memory by controlling dopamine receptor expression.•Let-7 is necessary for normal development of αβ MBn and learning in adult flies.•MiR-980, a memory suppressor, regulates memory formation through A2bp1.