Discovery of TAK-659 an Orally Available Investigational Inhibitor of Spleen Tyrosine Kinase (SYK).
Betty Lam,Yasuyoshi Arikawa, Joshua Cramlett,Qing Dong,Ron de Jong,Victoria Feher, Charles E. Grimshaw,Pamela J. Farrell,Isaac D. Hoffman,Andy Jennings,Benjamin Jones,Jennifer Matuszkiewicz,Joanne Miura,Hiroshi Miyake,Srinivasa Reddy Natala,Lihong Shi,Masashi Takahashi,Ewan Taylor,Corey Wyrick,Jason Yano,Jonathan Zalevsky,Zhe Nie Bioorganic & medicinal chemistry letters（2016）
关键词
SYK,Kinase inhibitor,Kinase selectivity,Structure-based drug discovery,Leukemia,Lymphoma
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