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Effect of Tdap when administered before, with or after the 13-valent pneumococcal conjugate vaccine (coadministered with the quadrivalent meningococcal conjugate vaccine) in adults: A randomised controlled trial

M. Tashani,M. Alfelali,O. Barasheed,A.S. Alqahtani,L. Heron,M. Wong,H. Rashid,R. Booy

Vaccine（2016）

Cited 9|Views32
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Abstract
•Carrier proteins on have similar antigens to the components of Tdap vaccine.•Prior exposure of conjugate vaccines to Tdap leads to carrier induced suppression.•Administering Tdap before PCV13 suppressed the GMTs of six of its antigens.
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Key words
Pneumococcal conjugate vaccine,Diphtheria and acellular pertussis vaccine,Carrier interference,Pneumococcal opsonophagocytic assay
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