Evaluation of biomarkers in the UK phase III VorteX trial confirms importance of tumour hypoxia in soft tissue sarcoma

Background: Research in soft tissue sarcoma (STS) is challenging due to its rarity and heterogeneity. Progress requires tailoring therapy to individual features of tumour biology, which need identifying in well documented cohorts. VorteX assessed whether a reduced volume of tissue irradiated post-operatively improves limb function in patients with extremity STS. The VorteX-Biobank created a linked bioresource.