Effects of Interferon-Gamma on Expression of Ceramide Synthases and Elongases of Long-Chain Fatty Acids in Cultured Human Keratinocytes

Ceramide (CER) with long-chain fatty acids (FAs) in human stratum corneum is important for the skin barrier functions. Changes in the CER profile have been associated with abnormal permeability of dermatoses such as atopic dermatitis (AD) and psoriasis. Interferon-gamma (IFN-gamma) has been known to be abundant in both AD and psoriatic skin lesions. However, it is unknown how IFN-gamma affects the synthasis of ceramides.