Influence of Glycosaminoglycan from Mactra Veneriformison Antiplatelet Aggregation

In this study, influence of glycosaminoglycan from Mactra veneriformis on antiplatelet aggregation in rats was studied. The results showed that glycosaminoglycan (GAG) from Mactra veneriformis could reduce the platele aggregation and the platelet adhesion rates of rats in vivo and in vitro (P<0.05, P<0.01), attenuate calcium ion concentration in rat platelets (P<0.01), increase cAMP concentration in rat platelets (P< 0.05, P<0.01), diminish TXB2 concentrationin in rat plasma (P<0.01), elevate 6-keto-PGF1a concentration in rat plasma (P<0.05, P<0.01) . This study suggests that GAG has obviously inhibitory effects on ADP-induced platelet aggregation in rats, which might account for its anti-thrombitic activity.