INTOXICATIE MET METHANOL EN ETHYLEENGLYCOL: KLINISCHE TOXICOLOGIE EN BEREKENING VAN DE OPTIMALE DOSIS ETHANOL ALS ANTIDOTUM

Frequently patients with an intoxication due to the intake of methanol or ethylene glycol are admitted to Dutch hospitals. With relatively simple analytical techniques the toxicological laboratory can analyse a serum sample and answer the question what and how much was ingested. After methanol or ethylene glycol ingestion, ethanol is the antidote of choice. In case of a methanol ingestion haemodialysis is indicated when methanol concentrations are above 500 mg/l, or when metabolic acidosis or visual impairment are present. In case of ethylene glycol ingestion, haemodialysis is indicated when ethylene glycol concentrations are above 500 mg/l, when vital signs deteriorate, or when metabolic acidosis or crystalluria are present. The calculation of the optimal dose of the antidote ethanol is illustrated by a case report of a methanol and ethylene glycol intoxication.