HISTOLOGICAL AND IMMUNOHISTOCHEMICAL IMPLICATIONS OF KETAMINE PROTRACTED DOSES AS A NOVEL CANDIDATE IN ANTIDEPRESSANT TREATMENTON ADULT RAT CEREBELLAR CORTEX.

Material/Methods:Thirty adult rats were divided into; group I (control), group II received IP injection of 5 mg/kg ketamine / 12 hours, and group III received IP injection of 20 mg/kg ketamine / 12 hours. After 14 days, cerebella were taken and prepared for histological study and immunohistochemical study for glial fibrillary acidic protein (GFAP) as a biomarker of neurotoxicity and for calretinin that plays an important role in the regulatory processes of calcium and has an anti-apoptotic cellular protective action.