Highly enantioselective Pd-catalyzed indole allylic alkylation using binaphthyl-based phosphoramidite-thioether ligands

A novel type of binaphthyl-based phosphoramidite-thioether ligand has been developed and successfully applied to Pd-catalysed asymmetric C-3 allylic alkylation of indoles, giving the desired products with up to 99% yield and 98% ee.