Asymmetric Aldol Reaction of Dichloroacetaldehyde Catalyzed by Diarylprolinol
Advanced Synthesis and Catalysis(2016)
摘要
The asymmetric cross‐aldol reaction of dichloroacetaldehyde with aldehyde pronucleophiles proceeds in the presence of a trifluoromethyl‐substituted diarylprolinol to afford γ,γ‐dichloro‐β‐hydroxy aldehydes in good yield with excellent enantioselectivity. The obtained products are useful synthetic intermediates; they were successfully converted to form chiral alkynes and dichloroalkenes.
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关键词
aldol reaction,asymmetric synthesis,dichloroacetaldehyde,organocatalysts
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