Clinical progress and pharmacology of small molecule bromodomain inhibitors
Current Opinion in Chemical Biology（2016）
Abstract
•Bromodomains are an exciting and important target class for drug discovery.•Multiple small molecule BET bromodomain inhibitors undergoing clinical trials with encouraging emerging data.•High quality chemical probes are an important tool for the target validation of non-BET bromodomains.•Increasing number of non-BET bromodomain chemical probes showing interesting pharmacology.
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